FBI Agent Will Graham has been called out of early retirement to catch a serial killer known by authorities as "The Tooth Fairy". He asks for the help of his arch-nemesis Dr. Hannibal "The Cannibal" Lecter so that he can catch "The Tooth Fairy" and bring him to justice. The only problem is that "The Tooth Fairy" is getting inside information about Graham and his family from none other than Dr. Lecter.